CDK5 Knockout Cell Line-293T

CDK5 Knockout Cell Line-293T

Cat.No.
CSC-RT0448
Description
293T-CDK5 (-/-) is a stable cell line with a homozygous knockout of human CDK5
Host Cell
293T
Background
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

For research use only. Not intended for any clinical use.

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