Human SCN10A/SCN3B Stable Cell Line-CHO

Name: Human SCN10A/SCN3B Stable Cell Line-CHO
SKU: CSC-RI0172
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0172

Host Cell : CHO Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0172
Description	This cell line is engineered to overexpress human SCN3B.
Background	The human Nav1.8 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in nociceptive peripheral neurons. Co-expression with the auxiliary beta 3 subunit promotes surface expression. The Nav1.8 channel is a therapeutic target in pain treatment.
Target Gene	SCN3B
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCN10A/SCN3B
Alias	SCN3B, HSA243396, SCNB3
Host Cell	CHO
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCN3B sodium channel, voltage-gated, type III, beta subunit [ Homo sapiens ]
Gene Symbol	SCN3B
Synonyms	SCNB3; HSA243396
Gene Description	sodium channel, voltage-gated, type III, beta
Gene ID	55800
Uni Prot ID	Q9NY72
m RNA Refseq	NM_001040151.1
Protein Refseq	NP_001035241.1
Chromosome Location	11q23.3
Function	ion channel binding; sodium channel regulator activity; sodium channel regulator activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential;
Pathway	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem;
MIM	608214

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