Rat Tert ORF Clone(NM_053423.1)

Name: Rat Tert ORF Clone(NM_053423.1)
SKU: CDCR380253
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR380253

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Product Information

Gene Information

Cat. No.	CDCR380253
Product Type	ORF Clone
Gene Abbr	Tert
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	3378 bp
Vector	pCMV6-Entry

Target Gene

TERT

Background

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

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