Human KCNJ2 Stable Cell Line-CHO

Name: Human KCNJ2 Stable Cell Line-CHO
SKU: CSC-RI0116
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0116

Host Cell : CHO Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0116
Description	This cell line is engineered to overexpress human KCNJ2.
Background	The human KCNJ2 gene encodes the pore-forming subunit of Kir2.1, an inwardly rectifying potassium channel. Mutations in KCNJ2 have been linked to inherited cardiac diseases including Andersens syndrome (a form of long QT with neurologic involvement), Short QT syndrome, and familial atrial fibrillation. Kir2.1 channels expressed in heart are anti-targets in cardiac risk assessment.
Target Gene	KCNJ2
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNJ2
Alias	KCNJ2, IRK1, Kir2.1, IRK-1, hIRK1, LQT7, SQT3, ATFB9, HHIRK1, KIR2.1, HHBIRK1
Host Cell	CHO
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 [ Homo sapiens ]
Gene Symbol	KCNJ2
Synonyms	IRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1
Gene Description	potassium inwardly-rectifying channel, subfamily J, member 2
GeneID	3759
Uni ProtID	P63252
mRNA Refseq	NM_000891.2
Protein Refseq	NP_000882.1
Chromosome Location	17q24.3
Function	identical protein binding; inward rectifier potassium channel activity;
Pathway	Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Classical Kir channels, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem;
MIM	600681

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