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Cat.No. : CSC-RI0106 Host Cell: CHO-K1
| Cat. No. | CSC-RI0106 |
| Description | This cell line is engineered to overexpress human KCNMB1. |
| Background | The KCNM1 gene encodes the pore-forming subunit of a large-conductance (260 pS single channel conductance), K+ -selective, channel that is activated by membrane depolarization and increased intracellular [Ca2+]. |
| Gene | KCNMB1 |
| Gene Species | Homo sapiens (Human) |
| Alias | KCNMB1, BKbeta, hbeta1, BKbeta1, K(VCA)beta |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The cell line was established by stably transfecting the human KCNMA1 (large conductance calcium-activated potassium channel alpha subunit) and KCNMB1 (beta subunit) genes into CHO cells.
A: It is primarily used to study the role of KCNMA1/KCNMB1 in cardiac cell electrophysiology and rhythm regulation.
A: It can be used to study the role of these channels in regulating neuronal excitability and neural signal transduction.
A: Special attention should be paid to the impact of drugs on KCNMA1/KCNMB1 channel activity and the resulting changes in cell electrophysiological properties.
A: It can be used to establish cellular models of cardiac and neurological diseases, especially those related to dysfunctions of the KCNMA1/KCNMB1 channels.
A: Regular monitoring of cell division and gene expression is necessary to ensure stable expression of the channel genes and consistency in cell characteristics.
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