Human KCNMA1 Stable Cell Line-CHO-K1

Name: Human KCNMA1 Stable Cell Line-CHO-K1
SKU: CSC-RI0105
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0105

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0105
Description	This cell line is engineered to overexpress human KCNMA1.
Background	The human KCNMA1 gene encodes the pore-forming subunit of KCa1.1, a calcium-activated BK potassium channel. KCa1.1 channels, widely distributed, are therapeutic targets in stroke, seizure, urinary incontinence, asthma, hypertension, gastric dysmotility, schizophenia, and prostate cancer.
Target Gene	KCNMA1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNMA1
Alias	KCNMA1, SLO, KCa1.1, mSLO1, hSlo, k(VCA)alpha, BKTM, SLO1, MaxiK, SAKCA, bA205K10.1, MGC71881, DKFZp686K1437
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [ Homo sapiens ]
Gene Symbol	KCNMA1
Synonyms	KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SLO; calcium-activated potassium channel subunit alpha-1; BK channel alpha subunit; KCa1.1; mSLO1; hSlo; k(VCA)alpha; slo homolog; slowpoke homolog; BKCA alpha subunit; maxi-K channel HSLO; stretch-activated Kca channel; calcium-activated potassium channel, subfamily M subunit alpha-1; BKTM; SLO1; MaxiK; SAKCA; SLO-ALPHA; bA205K10.1; MGC71881; DKFZp686K1437;
Gene ID	3778
Uni Prot ID	Q12791
m RNA Refseq	BC062659
Chromosome Location	10q22
Pathway	Ca2+ activated K+ channels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Neuronal System, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem; Platelet homeostasis, organism-specific biosystem;
MIM	600150

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