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Human KCNQ2/KCNQ4 Stable Cell Line-CHO

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Cat.No.
CSC-RI0146
Background
The human KCNQ2 and KCNQ4 genes encode the pore-forming subunits of Kv7.2 and Kv7.4, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ2 that reduce M-current are responsible for some forms of benign familial neonatal seizure. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.2/Kv7.4 channels are therapeutic targets in seizure and neuropathic pain.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
KCNQ4
Synonyms
KCNQ4; potassium voltage-gated channel, KQT-like subfamily, member 4; DFNA2; potassium voltage-gated channel subfamily KQT member 4; Kv7.4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; KV7.4; DFNA2A;
Gene ID
MIM
UniProt ID
P56696
Chromosome Location
1p34
Pathway
Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity;

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