Human KCNQ2/KCNQ4 Stable Cell Line-CHO

Name: Human KCNQ2/KCNQ4 Stable Cell Line-CHO
SKU: CSC-RI0146
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0146

Host Cell : CHO Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0146
Description	This cell line is engineered to overexpress human KCNQ4.
Background	The human KCNQ2 and KCNQ4 genes encode the pore-forming subunits of Kv7.2 and Kv7.4, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ2 that reduce M-current are responsible for some forms of benign familial neonatal seizure. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.2/Kv7.4 channels are therapeutic targets in seizure and neuropathic pain.
Target Gene	KCNQ4
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNQ2/KCNQ4
Alias	KCNQ4, DFNA2, Kv7.4, KV7.4, DFNA2A
Host Cell	CHO
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4 [ Homo sapiens ]
Gene Symbol	KCNQ4
Synonyms	DFNA2; KV7.4; DFNA2A
Gene ID	9132
Uni Prot ID	B3KQH8
m RNA Refseq	NM_004700.3
Protein Refseq	NP_004691.2
Chromosome Location	1p34
Function	potassium channel activity; voltage-gated potassium channel activity;
Pathway	Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	603537

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