Human KCNA4 Stable Cell Line-CHO-K1

Name: Human KCNA4 Stable Cell Line-CHO-K1
SKU: CSC-RI0029
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0029

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0029
Description	This cell line is engineered to overexpress human KCNA4.
Background	Kv1.4 is a voltage-gated, fast-inactivating, A-type potassium ion channel also known as HuK(II), hPCN2, HK1, RCK4, RHK1, RK4, RK8 and MK4. It is expressed in the CNS, lung, skeletal muscle, heart and pancreatic islet cells. It is responsibly for neuronal after hypolarization. The expression of Kv1.4 has been shown to increase after induction of diabetes and in ventricular myocytes after a heart attack.
Target Gene	KCNA4
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNA4
Alias	KCNA4, KCNA4L, HK1, HPCN2, Kv1.4, HBK4, PCN2, HUKII, KCNA8, KV1.4, KCNA4L
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 [ Homo sapiens ]
Gene Symbol	KCNA4
Synonyms	HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
GeneID	3739
Uni ProtID	P22459
mRNA Refseq	NM_002233.3
Protein Refseq	NP_002224.1
Chromosome Location	11p14
Function	potassium ion binding; protein binding; voltage-gated potassium channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176266

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