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Human CACNA1C/NEUROD1/CACNA2D1/KCNJ2 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0066
Background
The human CACNA1C gene encodes the pore-forming subunits of Cav1.2. Inclusion of auxiliary subunits modulate gating and pharmacological properties, while the inwardly rectifying potassium channel allows the membrane potential to be altered with changes in extracellular K+. Cav1.2 channels expressed in heart, smooth muscle, neurons, and endocrine tissue are therapeutic targets in cardiac arrhythmia and hypertension.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
NEUROD1
Synonyms
NEUROD1; neuronal differentiation 1; NEUROD, neurogenic differentiation 1; neurogenic differentiation factor 1; beta cell E box transactivator 2; BETA2; BHF 1; bHLHa3; MODY6; NeuroD; neurogenic helix loop helix protein NEUROD; beta-cell E-box transactivator 2; class A basic helix-loop-helix protein 3; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; BHF-1; NEUROD;
Gene ID
MIM
UniProt ID
Q13562
Chromosome Location
2q32
Pathway
Developmental Biology, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Regulation of beta-cell development, organism-specific biosystem; Regulation of gene expression in beta cells, organism-specific biosystem; Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, organism-specific biosystem;
Function
E-box binding; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription coactivator activity; chromatin binding; double-stranded DNA binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor binding;

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