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Human CACNA1D/CACNB3/CACNA2D1 + KCNJ2(tetracycline-inducible) Stable Cell Line-HEK293

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Cat.No.
CSC-RI0070
Background
The human CACNA1D gene encodes the pore-forming subunit of Cav1.3. CACNB3 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. The inducible expression of Kir2.1 provides a mechanism for K+-depolarization of the resting membrane potential to facilitate voltage-dependent activation of the Cav1.3 channels in FLIPR assays.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNJ2
Synonyms
KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; inward rectifier potassium channel 2; IRK1; Kir2.1; IRK-1; hIRK1; inward rectifier K+ channel KIR2.1; cardiac inward rectifier potassium channel; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1;
Gene ID
MIM
UniProt ID
P63252
Chromosome Location
17q24.3
Pathway
Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Classical Kir channels, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem;
Function
inward rectifier potassium channel activity; voltage-gated ion channel activity;

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