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Human KCNJ11/MED23 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0025
Background
Molecular cloning has identified the channel as a heteromer comprised of four pore-forming subunits, termed Kir 6.2, and four auxiliary sulphonylurea receptor subunits, Sur2A. The channel is gated by intracellular ATP and NDP while the Sur2A is regulated by both agonists, such as the potassium channel opener pinacidil, and antagonists, such as glibenclamide. In vivo the cardiac KATP channel is thought to be cardioprotective during periods of ischemic stress, as activation of the channel hyperpolarizes the cell, reducing calcium channel activity, leading to a shortening of the action potential duration.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
MED23
Synonyms
MED23; mediator complex subunit 23; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa , CRSP3; mediator of RNA polymerase II transcription subunit 23; CRSP130; DRIP130; Sur2; 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; vitamin D3 receptor interacting protein; activator-recruited cofactor 130 kDa component; cofactor required for Sp1 transcriptional activation subunit 3; SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP133; DKFZp434H0117;
Gene ID
MIM
UniProt ID
Q9ULK4
Chromosome Location
6q22.33-q24.1
Pathway
Developmental Biology, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem;
Function
protein binding; transcription coactivator activity;
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Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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