Human EDNRB Stable Cell Line-U2OS

Name: Human EDNRB Stable Cell Line-U2OS
SKU: CSC-RG0021
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0021

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0021
Background	The endothelins and their receptors are referred as the endothelin (ET) axis and this axis has been implicated in diverse tumours. Endothelin B receptor (ETB) may oppose cancer advance by helping apoptosis and clearing ET-1; however, it has recently been involved in the progress of some tumour as melanomas or oligodendrogliomas. The multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene.
Target Gene	EDNRB
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuEDNRB
Alias	EDNRB, ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	Homo sapiens endothelin receptor type B DNA.
Gene Symbol	EDNRB
Synonyms	ETB, ET-B, ETBR, ETRB, HSCR, WS4A, ABCDS, ET-BR, HSCR2
m RNA Refseq	BC014472

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Customer Reviews

Customer Q&As

How can the Human EDNRB Stable Cell Line-U2OS contribute to our understanding of the role of EDNRB in osteosarcoma progression?

A: The Human EDNRB Stable Cell Line-U2OS can contribute to our understanding of the role of EDNRB in osteosarcoma progression by facilitating in-depth studies on the molecular mechanisms, signaling pathways, and downstream effects of EDNRB activation in these cancer cells. This knowledge can provide valuable insights into potential therapeutic strategies.

Can the Human EDNRB Stable Cell Line-U2OS be used to study the effects of EDNRB agonists and antagonists on cellular behavior?

A: Yes, the Human EDNRB Stable Cell Line-U2OS can be employed to study the effects of EDNRB agonists and antagonists on cellular behavior. Researchers can utilize this cell line to investigate how various ligands or compounds interact with EDNRB and modulate cell signaling, proliferation, migration, or other functional responses.

Are there any known studies or publications that have utilized the Human EDNRB Stable Cell Line-U2OS?

A: As of my last training data update in January 2022, there were no specific studies or publications mentioned involving the Human EDNRB Stable Cell Line-U2OS. However, it is essential to consult the most recent scientific literature for any updates or relevant research.

What are the unique advantages of utilizing the Human EDNRB Stable Cell Line-U2OS for EDNRB-related research?

A: The Human EDNRB Stable Cell Line-U2OS offers the advantage of stable and consistent expression of EDNRB, enabling researchers to obtain reliable and reproducible results in their experiments. It provides a relevant human osteosarcoma cellular context for studying EDNRB, which can be particularly valuable for cancer research and drug development.

What is the specific research focus or purpose of creating the Human EDNRB Stable Cell Line-U2OS?

A: The creation of the Human EDNRB Stable Cell Line-U2OS aims to establish a dependable cellular model for studying the Endothelin B receptor (EDNRB) in human osteosarcoma (U2OS) cells. This facilitates investigations into the functional roles and signaling pathways associated with EDNRB in this specific cellular context.

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