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Human CHRM3 Stable Cell Line-U2OS

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Cat.No.
CSC-RG0014
Background
Muscarinic acetylcholine receptors are G protein-coupled receptors. M1, M3, M5 receptors couple to G proteins of the Gq/11 family, which activate phospholipase C. M2 and M4 receptors couple to Gi/o-type G proteins that inhibit adenylyl cyclase activity.Muscarinic receptors control many effects of acetylcholine in the central and peripheral nervous system. M3 receptor is found in smooth muscles, the endocrine glands, the exocrine glands, as well as the lungs. It is also found in the CNS, where it induces emesis. In general, it causes smooth muscle contraction and increased glandular secretions. M3 receptor is thought to be implicated in Alzheimer′s disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
CHRM3
Synonyms
CHRM3; cholinergic receptor, muscarinic 3; muscarinic acetylcholine receptor M3; acetylcholine receptor; muscarinic 3; m3 muscarinic receptor; acetylcholine receptor, muscarinic 3; HM3; EGBRS;
Gene ID
MIM
UniProt ID
P20309
Chromosome Location
1q41-q44
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; acetylcholine binding; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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