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Human EDNRB Stable Cell Line-CHO

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Cat.No.
CSC-RG0840
Background
Endothelins are a family of vasoactive peptides that includes ET-1, ET-2 and ET-3. To date, two subtypes of endothelin receptors have been identified from mammalian cells, EDNRA (ETA) and EDNRB (ETB). The EDNRA receptors have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The EDNRB receptors bind ET-1, ET-2 and ET-3 with nearly equal affinity and are expressed abundantly in endothelial cells and epithelial tissues. Although the vasoconstrictor and proliferative effects of ET-1 are primarily mediated by EDNRA receptors, EDNRB receptors can also mediate the vasoconstrictor response through ET-1-induced nitric oxide release from endothelial cells.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
EDNRB
Synonyms
EDNRB; endothelin receptor type B; HSCR, HSCR2; endothelin B receptor; ETB; endothelin receptor non-selective type; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2;
Gene ID
MIM
UniProt ID
P24530
Chromosome Location
13q22
Pathway
Arf6 trafficking events, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; endothelin receptor activity; endothelin receptor activity; endothelin receptor activity; peptide hormone binding; receptor activity; signal transducer activity;

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