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Human CTLA4 Stable Cell Line-CHO

Cat.No.
CSC-RO0048
Description
This cell line is a stably transfected cell line which expresses Human CTLA4 without any tag.
Host Cell
CHO-K1
Shipping
Dry ice
Source
CHO-K1
Species
Human
Subgroup
Human
Background
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Gene Information
Gene Symbol
CTLA4
Synonyms
CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
Gene ID
UniProt ID
P16410
mRNA Refseq
Protein Refseq
Chromosome Location
2q33
Function
protein binding;
Pathway
Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
MIM

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