Recombinant Human CTLA-4 (C-6His)

Name: Recombinant Human CTLA-4 (C-6His)
SKU: RP00335
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00335 Tag : C-6His

Expressed Region : Lys36-Asp161 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00335
Description	The Recombinant Human CTLA-4 (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Lys36-Asp161 with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol Weight	14.3 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Lys36-Asp161
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	CTLA4
Background	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Synonyms	Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4

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