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Cat.No. : CSC-RO0065 Host Cell: CHO-K1
| Cat. No. | CSC-RO0065 |
| Description | This cell line is a stably transfected cell line which expresses mouse tumor necrosis factor receptor superfamily, member 9 (Tnfrsf9) without any tag. |
| Background | Homozygous mutation of this gene results in enhanced T cell proliferation, decreased B cell IgG production, decreased cytotoxic T cell activity, and increased numbers of erythrocytes, granulocyte macrophages, and multipotential progenitor cells in the bone marrow, blood, and spleen. |
| Gene | Tnfrsf9 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Target | Mouse |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Gene Name | Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ] |
| Gene Symbol | Tnfrsf9 |
| Synonyms | ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik |
| Gene ID | 21942 |
| UniProt ID | P20334 |
| Chromosome Location | 4 E2; 4 81.52 cM |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: 4-1BB is a member of the tumor necrosis factor (TNF) receptor family.
A: Other names for 4-1BB include Tumor Necrosis Factor Receptor Superfamily Member 9 (TNFRSF9), CD137, and Inducible Lymphocyte Activation (ILA).
A: 4-1BB is expressed by activated T cells, but the expression level on CD8 is greater than on CD4 T cells.
A: 4-1BB expression is found on dendritic cells at inflammatory sites, follicular dendritic cells, natural killer cells, granulocytes, and vascular wall cells.
A: Cell surface protein expression can be verified by FACS or WB.
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