Human CD28 Stable Cell Line-HEK293T

The CD28 gene encodes a protein that plays a critical role in the immune response by facilitating communication between T cells and antigen-presenting cells. CD28 is a cell surface receptor that belongs to the immunoglobulin superfamily and is primarily expressed on the surface of helper T cells. CD28 is known to interact with two main counter-receptors, CD80 (B7-1) and CD86 (B7-2), which are expressed on the surface of antigen-presenting cells such as dendritic cells and macrophages. The interaction between CD28 and its counter-receptors is essential for the activation and proliferation of T cells, and for the production of cytokines that regulate the immune response. CD28 is particularly important in the context of graft-versus-host disease (GVHD), a potentially life-threatening condition that occurs after bone marrow transplantation. GVHD occurs when donor T cells recognize and attack host cells, and CD28-/- mice have been shown to be highly susceptible to this disease. Abnormal expression or mutations in the CD28 gene can lead to immune disorders. For example, CD28-/- mice have been shown to have defective T cell responses and are unable to clear certain infections. Additionally, CD28 has been found to play a role in the pathogenesis of autoimmune diseases such as type 1 diabetes and systemic lupus erythematosus. The CD28 gene is essential for the proper functioning of the immune system, particularly in facilitating the activation and proliferation of T cells. Dysregulation of CD28 expression or function can lead to immune disorders and compromised immune responses to infections and tumors. Further research into the role and regulation of the CD28 gene may contribute to the development of novel therapeutic strategies for the treatment of these conditions.