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Rat Ctla4 ORF Clone(NM_031674.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379827

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Gene Information

Cat. No. CDCR379827
Product Type ORF Clone
Gene Abbr Ctla4
Species Rat
Tag C-terminal Myc-DDK
ORF Size 672 bp
Vector pCMV6-Entry
Target Gene CTLA4
Background This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
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