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Human GRIN1/GRIN2A Stable Cell Line-HEK293

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Cat.No.
CSC-RI0174
Background
The human GRIN1/GRIN2A genes encode the cationic-selective, n-methyl-d-aspartic acid receptor-channel expressed in the CNS. NMDA receptors are therapeutic targets in treatment of neurological disorders including seizure, pain, and Alzheimer"s disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GRIN2A
Synonyms
GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; glutamate [NMDA] receptor subunit epsilon-1; GluN2A; hNR2A; NMDA receptor subtype 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; EPND; NR2A;
Gene ID
MIM
UniProt ID
Q12879
Chromosome Location
16p13.2
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem;
Function
ATPase binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; cell adhesion molecule binding; extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate receptor binding; ion channel activity; ionotropic glutamate receptor activity; metal ion binding; neurotransmitter binding; protein binding; protein kinase binding; receptor activity; transporter activity; voltage-gated cation channel activity; zinc ion binding;

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