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Rat Grin2a ORF Clone(NM_012573.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377309

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Product Information

Gene Information

Cat. No. CDCR377309
Product Type ORF Clone
Gene Abbr Grin2a
Species Rat
Tag C-terminal Myc-DDK
ORF Size 4395 bp
Vector pCMV6-Entry
Target Gene GRIN2A
Background This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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