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Human P2RX1 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0180
Background
The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation. P2X1 receptors are therapeutic targets in treatment of urinary incontinence and pain.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
P2RX1
Synonyms
P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1; P2X purinoceptor 1; P2X1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1;
Gene ID
MIM
UniProt ID
P51575
Chromosome Location
17p13.3
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Elevation of cytosolic Ca2+ levels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Platelet calcium homeostasis, organism-specific biosystem;
Function
ATP binding; calcium channel activity; cation channel activity; drug binding; extracellular ATP-gated cation channel activity; purinergic nucleotide receptor activity; receptor activity; zinc ion binding;

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