Human P2RX1 Stable Cell Line-HEK293

Name: Human P2RX1 Stable Cell Line-HEK293
SKU: CSC-RI0180

Cat.No. : CSC-RI0180 Host Cell: HEK293

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Cat. No.	CSC-RI0180
Description	This cell line is engineered to overexpress human P2RX1.
Background	The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation. P2X1 receptors are therapeutic targets in treatment of urinary incontinence and pain.
Gene	P2RX1
Gene Species	Homo sapiens (Human)
Alias	P2RX1, P2X1
Host Cell	HEK293
Host Cell Species	Homo sapiens (Human)
Morphology	Epithelial
Stability	Validated for at least 10 passages
Application	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Media Type	Cells were cultured in DMEM supplemented with 10% fetal bovine serum.
Freeze Medium	Complete medium supplemented with 10% (v/v) DMSO
Shipping	Dry ice
Storage	Liquid nitrogen

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm² flask containing pre-warmed media.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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