Human ADRA2B Stable Cell Line-CHO-K1

Name: Human ADRA2B Stable Cell Line-CHO-K1
SKU: CSC-RG0798
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0798

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0798
Background	Three alpha2-adrenoceptors have been cloned, and are designated alpha2A, alpha2B and alpha2C. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2 adrenergic receptor is widely distributed in the CNS, lung, blood vessels and skeletal muscle and mediates vasoconstriction and modulation of neurotransmission.
Target Gene	ADRA2B
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuADRA2B
Alias	ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ADRA2L1, ADRA2RL1, ALPHA2BAR
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ADRA2B adrenoceptor alpha 2B [ Homo sapiens ]
Gene Symbol	ADRA2B
Synonyms	ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
Gene Description	adrenergic, alpha-2B-, receptor
Gene ID	151
Uni Prot ID	A2RUS0
m RNA Refseq	NM_000682.5
Protein Refseq	NP_000673.2
Chromosome Location	2q11.1
Function	alpha2-adrenergic receptor activity; epinephrine binding; protein binding;
Pathway	Adrenaline signalling through Alpha-2 adrenergic receptor, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
MIM	104260

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