Recombinant Cynomolgus PD-1 (C-Fc)

Name: Recombinant Cynomolgus PD-1 (C-Fc)
SKU: RP00379

Cat.No. : RP00379 Tag: C-Fc

Expressed Region: Leu25-Gln167 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00379
Description	The Recombinant Cynomolgus PD-1 (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Leu25-Gln167 with a Fc tag at the C terminus.
Species	Cynomolgus
Tag	C-Fc
Mol. Weight	42.9 KDa
Expressed Region	Leu25-Gln167
Expression System	Human Cell
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	PD1
Background	Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Synonyms	Programmed cell death 1; PD-1; PD1

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