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Cat.No. : CSC-RO0687 Host Cell: CHO-K1
| Cat. No. | CSC-RO0687 |
| Description | This cell line is engineered to stably overexpress mouse CD40 antigen (CD40). |
| Gene | CD40 |
| Gene Species | Mus musculus (Mouse) |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Chinese hamster ovary (CHO) cells, specifically CHO-K1, are extensively utilized in biopharmaceuticals for producing monoclonal antibodies (mAbs), including immunoglobulin G (IgG). These cells are preferred due to their robust cell growth, effective post-translational modification capabilities, and adherence to good manufacturing practice (GMP) standards. CHO cells are key in achieving high and stable mAb production through genetic, transcriptional, and translational enhancements, as well as optimized culture conditions.
A: The Mouse CD40 Stable Cell Line - CHO-K1 is a cell line derived from Chinese hamster ovary cells (CHO-K1). It was created through genetic engineering techniques where the CD40 gene from mice was introduced into CHO-K1 cells. This modification allows CHO-K1 cells to express the mouse CD40 protein on their surface, making them a valuable tool for studying CD40-related signaling pathways and immune responses in a mammalian system.
A: The Mouse CD40 Stable Cell Line - CHO-K1 is primarily used in immunology and cell biology research. It serves as a model system to investigate various aspects of CD40-CD40L interactions, B cell activation, and immune responses. Researchers can use this cell line to study the downstream signaling pathways triggered by CD40 activation, screen for potential drug candidates targeting CD40, and assess the effects of different ligands or antibodies on CD40-mediated cellular responses.
A: When using the Mouse CD40 Stable Cell Line - CHO-K1, researchers should be aware of the following considerations:Ensure appropriate containment and biosafety measures, as these cells have been genetically modified.
Validate the stability of CD40 expression in the cell line over time to maintain experimental consistency.
A: The Mouse CD40 Stable Cell Line - CHO-K1 offers several advantages in CD40-related research: It allows for the study of CD40 signaling in a non-human mammalian system, which can provide insights into the conservation and divergence of CD40 functions.
CHO-K1 cells are well-characterized and have a stable karyotype, making them a reliable model for consistent experimental results.
A: The Mouse CD40 Stable Cell Line - CHO-K1 contributes to autoimmune disease and cancer immunotherapy research in several ways: It can be employed to study the role of CD40 activation in the immune response against cancer cells, potentially leading to the development of novel immunotherapeutic strategies.
By examining CD40-mediated B cell activation, researchers can gain insights into the pathogenesis of autoimmune diseases involving dysregulated immune responses.
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