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Human CD40 Stable Cell Line-CHO

See other products for CD40
Cat.No.
CSC-RO0044
Cell Line Description
This cell line is a stably transfected cell line which expresses Human CD40 without any tag.
Background
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3).
Host Cell
CHO-K1
Ship
Dry ice
Antigen Gene Information
Official Symbol
CD40
Synonyms
p50; Bp50; CDW40; TNFRSF5
GeneID
UniProt ID
P25942
Chromosome Location
20q13.12
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