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Cat.No. : CSC-RO0265 Host Cell: MSLN
| Cat. No. | CSC-RO0265 |
| Description | Human MSLN Stable Cell Line - U87 is engineered to stably overexpress human mesothelin (MSLN). |
| Gene | MSLN |
| Gene Species | Homo sapiens (Human) |
| Host Cell | MSLN |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Human MSLN Stable Cell Line - U87 is derived from the human glioblastoma cell line U87. U87 cells were initially isolated and established from human brain tissue in 1968. To establish the Human MSLN Stable Cell Line - U87, it is likely that U87 cells were transfected or stably engineered to express the mesothelin (MSLN) gene.
A: The genetic and phenotypic characteristics of Human MSLN Stable Cell Line - U87 may vary depending on the specific manipulations in the laboratory, but generally, they retain the genetic and phenotypic characteristics of U87 cells. U87 cells belong to the glioblastoma cell line and typically exhibit features of glial cells, such as a stellate glial cell morphology and the expression of neuronal markers.
A: Human MSLN Stable Cell Line - U87 has various research applications, including: Tumor biology research: It can be used to investigate the role of mesothelin (MSLN) in tumor development and metastasis, as well as therapeutic strategies targeting MSLN.
Drug screening: It can be employed for screening anti-tumor drugs or drugs targeting MSLN.
Immunotherapy research: It is used to assess the efficacy of immunotherapeutic strategies such as immune checkpoint inhibitors against tumor cells.
A: The biosafety level of Human MSLN Stable Cell Line - U87 is typically BSL-2, which stands for Biosafety Level 2. This means that appropriate biosafety measures should be taken when handling these cells to prevent potential infections, but extremely high-level biosafety precautions are usually not required.
A: When using Human MSLN Stable Cell Line - U87 for research, it is important to consider the following: Cell culture conditions: Maintain appropriate culture conditions, including temperature, CO2 concentration, and culture medium.
Infection control: Implement biosafety measures to prevent cell contamination and cross-contamination.
A: Human MSLN Stable Cell Line - U87 is associated with mesothelin (MSLN) because it is a cell line modified to express MSLN. MSLN is a membrane glycoprotein that is overexpressed in various cancer types, including pancreatic cancer, ovarian cancer, and mesothelioma. The association is important in research because it allows scientists to investigate the role of MSLN in cancer biology, explore potential therapeutic targets, and develop treatments for cancers that overexpress MSLN.
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