Human P2RY1 Stable Cell Line-1321N1

Name: Human P2RY1 Stable Cell Line-1321N1
SKU: CSC-RG0371
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0371

Host Cell : 1321N1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0371
Background	P2Y1 is a receptor for ATP and ADP. P2Y1 contributes to platelet shape change. A number of P2Y1 receptor-specific antagonists, such as, MRS-2179, A3P5PS, A3P5P and A2P5P have been discovered. They inhibit calcium ion mobilization and shape change in platelets. P2Y1-deficient mice and mice treated with the P2Y1 antagonist MRS2179 displayed significantly less arterial thrombosis than their respective controls. Combination of P2Y1 deficiency with P2Y12 inhibition led to a significant additive effect.
Target Gene	P2RY1
Gene Species	Homo sapiens (Human)
Abbr	1321N1-HuP2RY1
Alias	P2RY1, P2Y1
Host Cell	1321N1
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	P2RY1 purinergic receptor P2Y, G-protein coupled, 1 [ Homo sapiens ]
Gene Symbol	P2RY1
Synonyms	P2Y1
Gene ID	5028
Uni Prot ID	P47900
m RNA Refseq	NM_002563.3
Protein Refseq	NP_002554.1
Chromosome Location	3q25.2
Function	A1 adenosine receptor binding; ADP binding; ATP binding; G-protein coupled purinergic nucleotide receptor activity; protein heterodimerization activity; receptor activity; scaffold protein binding;
Pathway	ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem;
MIM	601167

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