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Human NPSR1 variant Asn107Ile cDNA (SNP591694 A>T; refSNP ID rs324981) Stable Cell Line-HEK293T

See other products for NPSR1
Cat.No.
CSC-RG0327
Background
Neuropeptide S (NPS) receptor 1 is also known as GPR154 or G proteincoupled receptor for asthma susceptibility (GPRA). NPS receptor is widely expressed in the brain, with highest levels found in hypothalamus, amygdala, endopiriform nucleus, cortex, subiculum and nuclei of the thalamic midline. Central administration of NPS promotes behavioral arousal and suppresses all stages of sleep in rodents. Furthermore, NPS was found to produce anxiolytic-like effects in a battery of four different tests that measure behavioral responses of rodents to novelty or stress. A number of polymorphisms in the human NPS receptor gene have been identified and a specific set of these polymorphisms was linked to an increased susceptibility for asthma and potentially other forms of allergy that are characterized by high IgE serum levels in Finnish and Canadian asthma patients. One of the single nucleotide polymorphisms Asn107Ile in the human receptor results in a gain-of-function characterized by an increase in agonist potency without changing binding affinity.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
NPSR1
Synonyms
NPSR1; neuropeptide S receptor 1; G protein coupled receptor 154 , GPR154; neuropeptide S receptor; GPRA; PGR14; G protein-coupled receptor 154; G-protein coupled receptor 154; G-protein coupled receptor PGR14; vasopressin receptor-related receptor 1; G protein-coupled receptor for asthma susceptibility; G-protein coupled receptor for asthma susceptibility; NPSR; VRR1; ASRT2; GPR154;
Gene ID
MIM
UniProt ID
Q6W5P4
Chromosome Location
7p14.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; vasopressin receptor activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-SC010571
HEK293 ,CHO, etc.
NPSR1
Human
CSC-RG0324
HEK293T
Npsr1
Mouse
Cat#
Product Name
Titer
Product Size
Species
Price
AD10961Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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