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Human KCNQ4 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0045
Background
KCNQ genes encode potassium channels that have been associated with both cardiac and hearing abnormalities in humans, most notably the KNCQ1 gene. Using a partial KCNQ3 cDNA Kubisch et al. screened a human retinal cDNA lambda phage library and obtained a novel homolog they named KCNQ4. When expressed in Xenopus oocytes KCNQ4 encodes a potassium current inhibited by 30% in the presence of 200 μM linopridine, whereas the current due to KCNQ3/KCNQ4 heteromers in the same study was inhibited by 75% at that concentration. Kubisch et al. also mapped the KCNQ4 gene to the 1p34 human chromosome, in a region associated with autosomal dominant deafness DFNA2A. Subsequent studies have identified additional families with mutations in KCNQ4 and hearing loss. KCNQ4-specific openers could possibly treat progressive hearing loss and tinnitus Kubisch et al..
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNQ4
Synonyms
KCNQ4; potassium voltage-gated channel, KQT-like subfamily, member 4; DFNA2; potassium voltage-gated channel subfamily KQT member 4; Kv7.4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; KV7.4; DFNA2A;
Gene ID
MIM
UniProt ID
P56696
Chromosome Location
1p34
Pathway
Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity;

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