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Human F2RL1 Stable Cell Line-CHO

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Cat.No.
CSC-RG0920
Background
Protease-activated receptor-2 (PAR2) belongs to a four-member family of GPCRs that are activated by proteases (see Ossovskaya et al for review). These proteases cleave a specific extracellular amino-terminal domain of the receptor to reveal a tethered ligand, which in turn activates the receptor which couples via Gq to release intracellular calcium (Nystedt, S. et al., 1995). PAR2 is expressed in the vasculature, GI tract, CNS, lung, kidney, liver, and heart. PAR2 is a relevant target for arthritis, inflammation, bowel disease, and cancer.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages (6 weeks of continuous culture)
Ship
Dry ice
Gene Information
Official Symbol
F2RL1
Synonyms
F2RL1; GPR11; PAR2; coagulation factor II (thrombin) receptor-like 1; G protein-coupled receptor-11; G-protein coupled receptor 11; PAR-2; coagulation factor II receptor-like 1; protease-activated receptor 2; proteinase-activated receptor 2; proteinase-activated receptor-2; thrombin receptor-like 1
Gene ID
MIM
UniProt ID
P55085
Chromosome Location
5q13
Pathway
African trypanosomiasis;

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