Human CALCR Stable Cell Line-HEK293

Name: Human CALCR Stable Cell Line-HEK293
SKU: CSC-RG0008
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0008

Host Cell : HEK293 Size : >1x10⁶ frozen cells/vial

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Gene Information

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Cat. No.	CSC-RG0008
Background	This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane spanning G protein coupled receptors. The protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
Target Gene	CALCR
Gene Species	Homo sapiens (Human)
Abbr	HEK293-HuCALCR
Alias	CALCR, CRT, CT-R, CTR, CTR1
Host Cell	HEK293
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Media Type	Cells were cultured in DMEM supplemented with 10% fetal bovine serum.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.
Freeze Medium	Complete medium supplemented with 10% (v/v) DMSO
Morphology	Epithelial

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CALCR calcitonin receptor [ Homo sapiens ]
Gene Symbol	CALCR
Synonyms	CALCR; calcitonin receptor; CTR; CRT; CT-R; CTR1;
GeneID	799
Uni ProtID	P30988
mRNA Refseq	BC069611
Chromosome Location	7q21.3
Function	calcitonin binding; NOT calcitonin binding; calcitonin binding; calcitonin receptor activity; calcitonin receptor activity; protein binding; protein transporter activity; receptor activity; receptor activity; signal transducer activity;
Pathway	Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
MIM	114131

CSC-RG0008-Human CALCR Stable Cell Line-HEK293-Datasheet

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What role does the Human CALCR Stable Cell Line-HEK293 play in studying signal transduction mediated by the Calcitonin receptor (CALCR)?

A: The Human CALCR Stable Cell Line-HEK293 serves as a model system for studying signal transduction mediated by the Calcitonin receptor (CALCR). By expressing CALCR in these cells, scientists can investigate how changes in downstream signaling pathways occur upon receptor activation and how these changes influence cellular behaviors.

How can the Human CALCR Stable Cell Line-HEK293 assist researchers in developing new drugs targeting CALCR?

A: The Human CALCR Stable Cell Line-HEK293 can assist researchers in developing new drugs targeting CALCR through drug screening experiments. These cells can be used in high-throughput screening platforms to evaluate the activity of compounds on CALCR, thereby revealing potential drug candidates.

What applications does the Human CALCR Stable Cell Line-HEK293 have in studying the endogenous regulation of CALCR?

A: The Human CALCR Stable Cell Line-HEK293 can be used to study the endogenous regulation mechanisms of CALCR within the cell, including its expression levels, subcellular localization, and interactions with other molecules.

What is the importance of the Human CALCR Stable Cell Line-HEK293 in studying the disease relevance of CALCR?

A: The Human CALCR Stable Cell Line-HEK293 is crucial for studying the role of CALCR in diseases. By simulating disease states in these cells, scientists can explore the role of CALCR in disease progression and potential therapeutic targets.

How does the Human CALCR Stable Cell Line-HEK293 assist in optimizing drug design during drug discovery?

A: The Human CALCR Stable Cell Line-HEK293 assists in optimizing drug design by providing direct evidence of drug action. By analyzing how drugs affect the function of CALCR, researchers can adjust the chemical structure of drugs to improve their potency and selectivity.

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Customer Reviews

A Practical CALCR Assay Platform

We found this CALCR stable cell line easy to incorporate into our receptor research workflow. Its HEK293 background supported routine culture and assay development, while the stable receptor expression helped improve consistency across experiments. It is a valuable model for ligand-response studies and preliminary compound evaluation.

United States

2025-02-01

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Human CALCR Stable Cell Line-HEK293

Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Documents

Q & A

Customer Reviews

What role does the Human CALCR Stable Cell Line-HEK293 play in studying signal transduction mediated by the Calcitonin receptor (CALCR)?

How can the Human CALCR Stable Cell Line-HEK293 assist researchers in developing new drugs targeting CALCR?

What applications does the Human CALCR Stable Cell Line-HEK293 have in studying the endogenous regulation of CALCR?

What is the importance of the Human CALCR Stable Cell Line-HEK293 in studying the disease relevance of CALCR?

How does the Human CALCR Stable Cell Line-HEK293 assist in optimizing drug design during drug discovery?

A Practical CALCR Assay Platform

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