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Human AVPR1B Validated Stable Cell Line-HEK293

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Cat.No.
CSC-RG1227
Background
Arginine vasopressin (AVP) is a 9 amino acid peptide that functions as an antidiuretic, vasoconstrictor and neurotransmitter. The three vasopressin receptors, V1A, V1B and V2, are GPCRs; V1A and V1B couple to Gq and calcium release, whereas V2 couples to Gs. The V1B receptor is expressed prominently in the anterior pituitary, where it mediates vasopressin-induced release of ACTH. A selective antagonist of V1B has recently been developed and shown to reduce depression, anxiety, and aggression in rodents.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
AVPR1B
Synonyms
AVPR1B; arginine vasopressin receptor 1B; AVPR3; vasopressin V1b receptor; V1bR; AVPR V3; AVPR V1b; vasopressin V3 receptor; arginine vasopressin receptor 3; antidiuretic hormone receptor 1B; pituitary vasopressin receptor 3;
Gene ID
MIM
UniProt ID
P47901
Chromosome Location
1q32
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled receptor activity; peptide hormone binding; protein homodimerization activity; protein kinase C binding; receptor activity; signal transducer activity; vasopressin receptor activity;

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