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Human AVPR1B Validated Stable Cell Line-HEK293

Cat.No.
CSC-RG1227
Abbr
HEK293-HuAVPR1B Validated
Alias
AVPR1B,AVPR3,V1bR
Growth Properties
Adherent
Host Cell
HEK293
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Arginine vasopressin (AVP) is a 9 amino acid peptide that functions as an antidiuretic, vasoconstrictor and neurotransmitter. The three vasopressin receptors, V1A, V1B and V2, are GPCRs; V1A and V1B couple to Gq and calcium release, whereas V2 couples to Gs. The V1B receptor is expressed prominently in the anterior pituitary, where it mediates vasopressin-induced release of ACTH. A selective antagonist of V1B has recently been developed and shown to reduce depression, anxiety, and aggression in rodents.

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