Human CD24 Stable Cell Line - MC38

Name: Human CD24 Stable Cell Line - MC38
SKU: CSC-RO0921

Cat.No. : CSC-RO0921 Host Cell: MC38

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RO0921
Description	This cell line is engineered to stably overexpress human CD24.
Gene	CD24
Gene Species	Homo sapiens (Human)
Host Cell	MC38
Host Cell Species	Mus musculus (Mouse)
Stability	Validated for at least 10 passages
Application	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Shipping	Dry ice
Storage	Liquid nitrogen

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm² flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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What are the key characteristics of the Human CD24 Stable Cell Line - MC38?

A: The Human CD24 Stable Cell Line - MC38 is characterized by the stable expression of the human CD24 gene in MC38 mouse colon cancer cells, making it a valuable tool for studying CD24-related mechanisms in the tumor microenvironment.

How can the Human CD24 Stable Cell Line - MC38 be employed to investigate the role of CD24 in tumor immune evasion?

A: Researchers can use the Human CD24 Stable Cell Line - MC38 to simulate CD24 expression in tumors and explore its impact on immune evasion mechanisms, providing insights into potential immunotherapeutic strategies.

Are there any specific challenges associated with maintaining the Human CD24 Stable Cell Line - MC38 in culture?

A: Maintaining the stability of the Human CD24 Stable Cell Line - MC38 in culture may require regular monitoring of CD24 expression levels and optimization of culture conditions to ensure reliable research results.

What innovative approaches can be employed using the Human CD24 Stable Cell Line - MC38 to study tumor immune evasion mechanisms?

A: The Human CD24 Stable Cell Line - MC38 can be used to investigate the crosstalk between CD24 and other immune checkpoint molecules, potentially leading to the development of novel immunotherapy strategies.

How can researchers address potential cytotoxicity or adaptability issues when working with the Human CD24 Stable Cell Line - MC38?

A: Addressing potential cytotoxicity or adaptability issues may involve fine-tuning culture conditions, selecting suitable culture media, and optimizing cell culture techniques.

What is the current state of research regarding the application of the Human CD24 Stable Cell Line - MC38 in preclinical studies?

A: The Human CD24 Stable Cell Line - MC38 is actively used in preclinical studies to investigate CD24-mediated immune evasion and evaluate potential immunotherapeutic interventions. These studies contribute to our understanding of tumor immunology.

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