Human CCR2 Stable Cell Line - HEK293T

Human CCR2 encodes a CC chemokine receptor central to monocyte recruitment and inflammatory-cell trafficking. Its activation by CCL2 and related CCR2 chemokines initiates Gi/o-dependent signaling that can promote calcium flux, chemotaxis, and cytoskeletal responses, making receptor abundance and cellular context important determinants of experimental response. This product is a stable HEK293T cell line engineered to maintain elevated expression of human CCR2. This cell line is engineered to stably overexpress Human CCR2 in HEK293T cells. HEK293T cells combine a human cellular background with high transfection efficiency and convenient propagation, making them useful for follow-on genetic manipulation and assay development. Stable integration reduces the experiment-to-experiment variability associated with transient transfection and supports repeated use across assay campaigns.

Functionally, the line is intended to provide consistent access to human CCR2-dependent biology. It is particularly suitable for ligand-response studies, antagonist screening, receptor binding, calcium or second-messenger assays, and investigation of inflammatory, fibrotic, metabolic, cardiovascular, or tumor-microenvironment pathways involving the CCL2-CCR2 axis. As a defined receptor-overexpression model, the cell line complements primary cells and tissue-derived systems by isolating target-dependent signaling from the complexity of mixed receptor populations. Its stable phenotype supports comparative pharmacology across compound series, biologic formats, and repeated screening campaigns, while preserving the same host-cell background for mechanistic interpretation. Receptor-focused datasets generated with this line can clarify ligand potency, efficacy, selectivity, desensitization, and internalization within a single cellular context. The platform is also relevant to comparative studies of small molecules, peptides, antibodies, and other biologic modulators directed at the same signaling axis.