Human CCR2 Stable Cell Line-CHO-K1

Name: Human CCR2 Stable Cell Line-CHO-K1
SKU: CSC-RG0823
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0823

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0823
Target Gene	CCR2
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuCCR2
Alias	CCR2, CMKBR2, CC CKR 2, CD192, CKR2, FLJ78302, MCP 1 R, CCR2A, CCR2B, CKR2A, CKR2B, MCP-1-R, CC-CKR-2
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CCR2 chemokine (C-C motif) receptor 2 [ Homo sapiens ]
Gene Symbol	CCR2
Synonyms	CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
Gene ID	729230
Uni Prot ID	P41597
m RNA Refseq	BC126452
Chromosome Location	3p21.31
Function	C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity;
Pathway	Beta defensins, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
MIM	601267

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Chemokines are a family of low molecular weight secreted proteins that act as leukocyte specifie chemoattractants. There are over 40 known chemokines which can be divided into four families: CXC, CC, C and CX3C. The CC-chemokines MCP-1,2,3,4 bind and activate CCR2 receptors. CCR2 receptors belong to the GPCR family and couple to the Gi signal pathway. CCR2 receptors are expressed on monocytes, macrophages, basophils, mast cells, T lymphocytes, NK cells and dendritic cells. There are two alternatively spliced forms of CCR2 receptors CCR2A and CCR2B, which differ only in their carboxyl-terminal tails. CCR2 receptors plays important roles in the recruitment of monocytes/macrophages, T cells and relates to many diseases such as inflammation, HIV, and pulmonary fibrosis.

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