Caspase-2 Activity Assay Kit

Name: Caspase-2 Activity Assay Kit
SKU: PTAK-003

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-003

Description

The Caspase-2 Assay Kit is used for detecting the activity of caspases that recognize the sequence VDVAD using fluorometric method. The assay is based on detection of cleavage of substrate VDVAD-AFC (AFC:7-amino-4- trifluoromethyl coumarin).

Applications

Useful for assaying the activity of caspase-2

Caution

Avoid freeze/thaw cycles

Component

•Caspase-2
•Caspase-2 assay buffer
•Caspase-2 substrate (VDVAD-AFC)
•DTT
•Caspase-2 inhibitor (Z-VAD-FMK)
•Microtiter plate

Method

Fluorescence

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is Caspase-2?

A: Caspase-2 is a protein enzyme that plays a critical role in the process of programmed cell death, also known as apoptosis.

What cellular processes are involved in Caspase-2?

A: Caspase-2 is part of a family of enzymes called caspases, which are involved in various cellular processes, including cell death, inflammation, and immune responses.

What is the role of caspase-2 in apoptosis?

A: In the intrinsic pathway, caspase-2 acts upstream of other caspases, cleaving and activating them to further facilitate the apoptotic process. It can directly cleave and activate downstream executioner caspases such as caspase-3, -6, and -7, which are responsible for executing cell death by cleaving specific cellular targets.

What diseases are caspase-2 associated with?

A: Dysregulation or malfunction of caspase-2 has been associated with various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.

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