Caspase-5 Activity Assay Kit

Name: Caspase-5 Activity Assay Kit
SKU: PTAK-006
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : PTAK-006

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Product Information

Cat. No.	PTAK-006
Description	The Caspase-5 Activity Assay Kit provides a simple and convenient colorimetric assay to measure Caspase-5 activity within 1-2 hrs. The kit provides a means for assaying the activity of caspase-5 and related caspases that recognize the sequence WEHD.
Component	•Caspase-5 •Caspase-5 assay buffer •Caspase-5 substrate (WEHD-pNA) •DTT •Dilution Buffer
Applications	Useful for assaying the activity of caspase-5
Size	100 assays
Method	Colorimetric
Caution	Avoid freeze/thaw cycles

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What is caspase-5?

A: Caspase-5, also known as ICE-protease-1 or ICH-2, is an enzyme that belongs to the caspase family of proteases.

Where is caspase-5 primarily expressed?

A: Caspase-5 is primarily expressed in the immune cells, specifically monocytes and macrophages.

What is the function of caspase-5?

A: Caspase-5 plays a role in the inflammatory response and activation of the immune system.

What is the role of caspase-5 in apoptosis?

A: Caspase-5 serves as an important mediator in the innate immune response against bacterial infections, by triggering the inflammatory pathway of apoptosis.

How is caspase-5 activated?

A: Caspase-5 is activated during the detection of cytosolic bacterial lipopolysaccharides (LPS). When bacterial infection occurs, certain immune cells recognize the presence of LPS in the cytoplasm. This triggers the formation of a complex called the inflammasome, which includes caspase-5.

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