Caspase-8 Activity Assay Kit

Name: Caspase-8 Activity Assay Kit
SKU: PTAK-009
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : PTAK-009

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Cat. No.	PTAK-009
Description	The Caspase-8 Assay Kit is a complete assay system designed to measure Caspase-8 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent Caspase-8 activity measurements. In addition, the kit includes purified Caspase-8 enzyme and a potent Caspase-8 inhibitor, Ac-IETD-CHO, for use as a positive and negative control. Using this kit, only one simple step on a microtiter plate is needed to analyze the Caspase-8 activity level. The fluorogenic substrate, Ac-IETD-AFC, is incubated with purified Caspase-8 and the enzymatic activity releases AFC fluorophore that can then be measured using a fluorescence reader.
Component	•Caspase-8 •Caspase-8 assay buffer •Caspase-8 substrate •DTT •Caspase-8 inhibitor (Ac-IETD-SHO) •Microtiter plate
Applications	Great for studying enzyme kinetics and HTS applications.
Size	100 assays
Method	Fluorescence
Caution	Avoid freeze/thaw cycles

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What is caspase-8?

A: Caspase-8 is also known as "apoptotic protease activating factor 1" (APAF1). It is an enzyme that plays a key role in initiating apoptosis, which is a process of programmed cell death.

What is the role of caspase-8 in apoptosis?

A: Caspase-8 is involved in initiating the extrinsic pathway of apoptosis, which is triggered by external signals such as cell surface death receptors.

What diseases are caspase-8 associated with?

A: Caspase-8 is essential for maintaining normal cellular homeostasis and development, and its dysregulation has been associated with various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

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