ACE2 Activity Assay Kit

Name: ACE2 Activity Assay Kit
SKU: PTAK-033

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-033

Description

The ACE2 Activity Assay Kit utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. We also provide an ACE2 specific inhibitor that can differentiate the ACE2 activity from other proteolytic activity.The kit can detect as low as 0.4 mU. Our assay kit is simple and can be used in a high-throughput format

Applications

Useful for detecting the activity of ACE2 protease in tissue/cell lysates and enzyme preparations.

Caution

Avoid freeze/thaw cycles

Component

•Active ACE2 protease
•ACE2 protease substrate
•ACE2 assay buffer
•ACE2 inhibitor
•MCA standard

Method

Fluorescence

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is ACE2?

A: ACE2 stands for angiotensin-converting enzyme 2. It is a protein found on the surface of cells in various organs of the body, including the lungs, heart, kidneys, and intestines.

What is the function of ACE2?

A: ACE2 plays a crucial role in the regulation of the renin-angiotensin-aldosterone system (RAAS), which controls blood pressure and fluid balance in the body.

What is the role of ACE2 in SARS-CoV-2?

A: ACE2 is the receptor that allows the entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, into human cells. The virus binds to ACE2 on respiratory epithelial cells and gains entry into the host cells, leading to infection and subsequent respiratory symptoms.

Does ACE2 cause vasoconstriction?

A: One of the most well-characterized functions of ACE2 is its role in regulating vascular tone. ACE2 induces vasodilation and attenuates Ang II-induced vasoconstriction through its effector peptide Ang-(1-7) and receptor Mas1.

What is the role of ACE2 in heart diseases?

A: ACE2 is also involved in cardiovascular health and the maintenance of blood pressure. Imbalances in the RAAS, including a decreased ACE2 expression or function, have been associated with various heart diseases, such as hypertension, heart failure, and atherosclerosis.

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