Factor XIIa Activity Assay Kit

Name: Factor XIIa Activity Assay Kit
SKU: PTAK-035

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-035

Description

The Factor XIIa Activity Assay Kit utilizes the ability of factor XIIa to cleave a synthetic substrate to release p-Nitroaniline (pNA) which can be quantitatively measured by a colorimetric assay (OD405 nm). The kit is easy-to-use and can detect Factor XIIa (as low as 1 mPEU) from plasma sampless.

Applications

Useful for detecting the activity of Factor XIIa.

Caution

Avoid freeze/thaw cycles

Component

•FXIIa Assay Buffer
•FXIIa Activator
•FXIIa Substrate
•Human Factor XIIa
•FXIIa Inhibitor
•pNA Standard

Method

Colorimetric

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is Factor XIIa?

A: Factor XIIa is a serine protease that plays a critical role in the intrinsic pathway of blood coagulation. It is the activated form of coagulation Factor XII (FXII).

What is the size of Factor XIIa?

A: The size of Factor XIIa (activated Factor XII) is approximately 80 kilodaltons (kDa).

What is the role of Factor XIIa in hereditary angioedema (HAE)?

A: In some individuals with HAE, Factor XIIa has been found to be overactive, leading to excessive activation of the bradykinin pathway. Blockade or inhibition of Factor XIIa has shown promising results in attenuating the symptoms of HAE.

What is the role of Factor XIIa in blood coagulation?

A: Factor XIIa helps activate Factor XI, which in turn activates Factor IX. Factor IX then activates Factor X, leading to the formation of thrombin and the conversion of fibrinogen into fibrin. Fibrin forms a meshwork that stabilizes the blood clot.

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