Cathepsin D Activity Assay Kit

Name: Cathepsin D Activity Assay Kit
SKU: PTAK-019

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-019

Description

The Cathepsin D Activity Assay kit is a fluorescence-based assay that utilizes the preferred cathepsin D substrate sequence GKPILFFRLK (Dnp)-DR-NH2 labeled with MCA. The cathepsin D assay is simple, straightforward, and can be adapted to 96-well plate assays. Assay conditions have been optimized to obtain the maximal activity.

Applications

Useful for detecting the activity of Cathepsin D

Caution

Avoid freeze/thaw cycles

Component

•Cathepsin D
•CTSD substrate (DR-NH2)
•Cathepsin assay buffer
•CTSD inhibitor

Method

Fluorescence

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is cathepsin D?

A: Cathepsin D is an enzyme that belongs to a family of lysosomal proteases known as cathepsins.

Where is cathepsin D primarily expressed?

A: Cathepsin D is primarily found in the lysosomes, which are cellular compartments involved in the degradation and recycling of various biomolecules.

What is the function of cathepsin D?

A: Cathepsin D is responsible for the hydrolysis of proteins, particularly those targeted for degradation. It cleaves peptide bonds within proteins, breaking them down into smaller peptides and amino acids.

What is the role of cathepsin D in physiological processes?

A: Cathepsin D is involved in many physiological processes, including protein turnover, antigen presentation, and programmed cell death (apoptosis).

What diseases are cathepsin D associated with?

A: Abnormalities in cathepsin D's activity or expression have been associated with cancer progression, neurodegenerative disorders (such as Alzheimer's and Parkinson's diseases), and cardiovascular diseases.

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