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Rat Tshr Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0271
Background
The thyroid stimulating hormone receptor (TSHR) is expressed in the membrane of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function. TSHR is also the target autoantigen in thyroid autoimmune diseases. Autoantibodies to TSHR that act as agonists are responsible for the hyperthyroidism of Graves" Disease. Another class of autoantibodies that block the binding of TSH to TSHR may mediate the hypothyroidism associated with Hashimoto"s thyroiditis, primary myxoedema, and neonatal hypothyroidism.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
Tshr
Synonyms
TSHR; thyroid stimulating hormone receptor; thyrotropin receptor; TSH-R; thyroid-stimulating hormone receptor; TSHRA;
Gene ID
Pathway
Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Hormone ligand-binding receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; thyroid-stimulating hormone receptor activity;

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