Rat Oprm1 Stable Cell Line-CHO dhfr-

Name: Rat Oprm1 Stable Cell Line-CHO dhfr-
SKU: CSC-RG0344
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0344

Host Cell : CHO dhfr- Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0344
Background	Mu opioid receptor (MOR) is a receptor for beta-endorphin, inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. MOR signaling and regulation are strongly agonist-dependent. MOR mediates positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation. MOR plays a genetic role in the control of gut inflammation. MOR-deficient mice are highly susceptible to colon inflammation, with a 50% mortality rate occurring 3 days after administration of TNBS that induces inflammation. MOR agonists regulate cytokine production and T cell proliferation and might be new therapeutic molecules in inflammatory bowel disease.
Target Gene	Oprm1
Abbr	CHO dhfr--RatOprm1
Alias	OPRM1, MOR-1, MUOR1, M-OR-1, MORA, Oprm, Oprrm1
Host Cell	CHO dhfr-
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	Oprm1 opioid receptor, mu 1 [ Mus musculus ]
Gene Symbol	OPRM1
Synonyms	mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O
Gene ID	18390
Uni Prot ID	P42866
m RNA Refseq	NM_001039652.1
Protein Refseq	NP_001034741.1
Chromosome Location	10 A2; 10 8.0 cM
Function	G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; beta-endorphin receptor activity; morphine receptor activity; opioid receptor activity; protein binding; signal transducer activity;
Pathway	Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G-protein activation, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Non-odorant GPCRs, organism-specific biosystem; Opioid Signalling, organism-specific biosystem; Peptide GPCRs, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;

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