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Rat Oprm1 Stable Cell Line-CHO dhfr-

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Cat.No.
CSC-RG0344
Background
Mu opioid receptor (MOR) is a receptor for beta-endorphin, inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. MOR signaling and regulation are strongly agonist-dependent. MOR mediates positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation. MOR plays a genetic role in the control of gut inflammation. MOR-deficient mice are highly susceptible to colon inflammation, with a 50% mortality rate occurring 3 days after administration of TNBS that induces inflammation. MOR agonists regulate cytokine production and T cell proliferation and might be new therapeutic molecules in inflammatory bowel disease.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO dhfr-
Ship
Dry ice
Gene Information
Official Symbol
Oprm1
Synonyms
OPRM1; opioid receptor, mu 1; mu-type opioid receptor; MOR-1; MUOR1; M-OR-1; opioid receptor B; mu opioid receptor; MORA; Oprm; Oprrm1;
Gene ID
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G-protein activation, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Morphine addiction, organism-specific biosystem;
Function
G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; G-protein coupled receptor activity; beta-endorphin receptor activity; morphine receptor activity; opioid receptor activity; protein binding; receptor activity; signal transducer activity;

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