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Rat Chrm4 Stable Cell Line-CHO

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Cat.No.
CSC-RG0877
Background
Muscarinic acetylcholine receptors are relatively abundant and mediate many of the diverse actions of acetylcholine in the CNS, as well as throughout non-nervous tissues innervated by the parasympathetic nervous system. There are five muscarinic receptor subtypes referred to as M1, M2, M3, M4 and M5 which belong to GPCR superfamily. The odd-numbered muscarinic receptors (M1, M3, M5) couple efficiently through Gq/11, to activate of phospholipase C, that initiates the phosphatidylinositol turnover response. The even-numbered muscarinic receptors (M2, M4) inhibit adenylyl caclase activity via activation of the Gi class of G proteins. M2 and M4 receptors also activate G protein-coupled potassium channel, which leads to hyperpolarization of the plasma membrane of excitable cells.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
Chrm4
Synonyms
CHRM4; cholinergic receptor, muscarinic 4; muscarinic acetylcholine receptor M4; cholinergic receptor, muscarin 4; M4;
Gene ID
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; protein binding; receptor activity; signal transducer activity;

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