Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)
  Email:

Rat Chrm4 Stable Cell Line-CHO

Cat.No.
CSC-RG0877
Abbr
CHO-RatChrm4
Alias
CHRM4,M4
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Rat
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Background
Muscarinic acetylcholine receptors are relatively abundant and mediate many of the diverse actions of acetylcholine in the CNS, as well as throughout non-nervous tissues innervated by the parasympathetic nervous system. There are five muscarinic receptor subtypes referred to as M1, M2, M3, M4 and M5 which belong to GPCR superfamily. The odd-numbered muscarinic receptors (M1, M3, M5) couple efficiently through Gq/11, to activate of phospholipase C, that initiates the phosphatidylinositol turnover response. The even-numbered muscarinic receptors (M2, M4) inhibit adenylyl caclase activity via activation of the Gi class of G proteins. M2 and M4 receptors also activate G protein-coupled potassium channel, which leads to hyperpolarization of the plasma membrane of excitable cells.

Quick Inquiry

   Please input "biogene" as verification code.