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Human CHRM4 Stable Cell Line-CHO

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Cat.No.
CSC-RG0878
Background
The five muscarinic receptor subtypes all mediate the action of acetylcholine. The odd-numbered receptors (m1, m3, and m5) couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, whereas the even-numbered receptors (m2, m4) are efficiently coupled to Gi and lead to inhibition of intracellular cAMP along with several other signal transduction pathways.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CHRM4
Synonyms
CHRM4; cholinergic receptor, muscarinic 4; muscarinic acetylcholine receptor M4; acetylcholine receptor; muscarinic 4; acetylcholine receptor, muscarinic 4; HM4; M4R;
Gene ID
MIM
UniProt ID
P08173
Chromosome Location
11p12-p11.2
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

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