Human TACR3 Stable Cell Line-U2OS

Name: Human TACR3 Stable Cell Line-U2OS
SKU: CSC-RG0016
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0016

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

Inquire for Price

Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0016
Background	Tachykinin receptor 3 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR3 is distributed throughout the CNS and it is found in high levels in the cerebral cortex, basal ganglia and dorsal horn of the spinal cord. TACR3 ligands are used in clinical trials for treatment of schizophrenia and other indications.
Target Gene	TACR3
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuTACR3
Alias	TACR3, NK-3R, NK3R, NKR, TAC3RL
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	TACR3 tachykinin receptor 3 [ Homo sapiens ]
Gene Symbol	TACR3
Synonyms	TACR3; tachykinin receptor 3; neuromedin-K receptor; neurokinin beta receptor; NK3R; NK-3 receptor; neurokinin B receptor; NKR; NK-3R; TAC3RL; MGC148060; MGC148061;
GeneID	6870
Uni ProtID	P29371
mRNA Refseq	BC122551
Chromosome Location	4q25
Function	G-protein coupled receptor activity; receptor activity; signal transducer activity; tachykinin receptor activity;
Pathway	Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
MIM	162332

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What is the role of the Human TACR3 Stable Cell Line-U2OS in studying the regulation of neurotransmitter release?

A: The Human TACR3 Stable Cell Line-U2OS, which stably expresses the human neurotoxin receptor 3 (TACR3) in U2OS cells, simulates the regulatory mechanisms of neurotransmitter release. This cell line is significant for understanding the specific role of TACR3 in neural transmission, particularly in the presynaptic regulation of neurotransmitter release.

How does the Human TACR3 Stable Cell Line-U2OS assist in drug screening to identify potential neuromodulators?

A: Drug screening on the Human TACR3 Stable Cell Line-U2OS allows researchers to evaluate the affinity and functional effects of drugs on the TACR3 receptor. This cell line provides a platform for identifying drugs that may influence neural transmission and neural function, which is valuable for developing new neuromodulators.

How is the Human TACR3 Stable Cell Line-U2OS applied in studying the role of TACR3 receptors in neurodegenerative diseases?

A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in neurodegenerative diseases, such as Parkinson's disease. This cell line helps scientists understand the expression and functional changes of TACR3 receptors in these diseases and how they affect the survival and death of neural cells.

How is the Human TACR3 Stable Cell Line-U2OS applied in exploring the role of TACR3 receptors in emotional regulation?

A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in emotional regulation, particularly in the emotional regulatory regions of the brain. This cell line helps scientists uncover how TACR3 receptors influence emotional states, which is valuable for understanding the mechanisms of mood-related disorders such as depression and anxiety.

How is the Human TACR3 Stable Cell Line-U2OS applied in studying the role of TACR3 receptors in pain perception?

A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in pain perception, particularly in pain signal transmission and pain threshold regulation. This cell line helps scientists understand the molecular mechanisms of TACR3 receptors in pain perception, which is significant for developing new pain management strategies.

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *