Cat.No. : CSC-RG0016 Host Cell: U2OS
| Cat. No. | CSC-RG0016 |
| Background | Tachykinin receptor 3 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR3 is distributed throughout the CNS and it is found in high levels in the cerebral cortex, basal ganglia and dorsal horn of the spinal cord. TACR3 ligands are used in clinical trials for treatment of schizophrenia and other indications. |
| Gene | TACR3 |
| Gene Species | Homo sapiens (Human) |
| Alias | TACR3, NK-3R, NK3R, NKR, TAC3RL |
| Host Cell | U2OS |
| Host Cell Species | Homo sapiens (Human) |
| Morphology | Epithelial |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human TACR3 Stable Cell Line-U2OS, which stably expresses the human neurotoxin receptor 3 (TACR3) in U2OS cells, simulates the regulatory mechanisms of neurotransmitter release. This cell line is significant for understanding the specific role of TACR3 in neural transmission, particularly in the presynaptic regulation of neurotransmitter release.
A: Drug screening on the Human TACR3 Stable Cell Line-U2OS allows researchers to evaluate the affinity and functional effects of drugs on the TACR3 receptor. This cell line provides a platform for identifying drugs that may influence neural transmission and neural function, which is valuable for developing new neuromodulators.
A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in neurodegenerative diseases, such as Parkinson's disease. This cell line helps scientists understand the expression and functional changes of TACR3 receptors in these diseases and how they affect the survival and death of neural cells.
A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in emotional regulation, particularly in the emotional regulatory regions of the brain. This cell line helps scientists uncover how TACR3 receptors influence emotional states, which is valuable for understanding the mechanisms of mood-related disorders such as depression and anxiety.
A: The Human TACR3 Stable Cell Line-U2OS can be used to study the role of TACR3 receptors in pain perception, particularly in pain signal transmission and pain threshold regulation. This cell line helps scientists understand the molecular mechanisms of TACR3 receptors in pain perception, which is significant for developing new pain management strategies.
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