Human P2RY12 Stable Cell Line-1321N1

Name: Human P2RY12 Stable Cell Line-1321N1
SKU: CSC-RG0374
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0374

Host Cell : 1321N1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0374
Background	P2RY12 or P2Y12 is a G-protein coupled receptor for ADP and ATP. ADT released from platelets acts in a positive feedback mechanism on P2Y12 and P2Y1 on platelets and is critical for sustained aggregation and stabilization of thrombin. P2Y12 receptor plays a central role in platelet activation and is the target of of antithrombotic drugs such as ticlopidine and clopidogrel.
Target Gene	P2RY12
Gene Species	Homo sapiens (Human)
Abbr	1321N1-HuP2RY12
Alias	P2RY12, HORK3, P2Y12, SP1999, ADPG-R, BDPLT8, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc)
Host Cell	1321N1
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	P2RY12 purinergic receptor P2Y, G-protein coupled, 12 [ Homo sapiens ]
Gene Symbol	P2RY12
Synonyms	HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2YR; P2Y(ADP); P2Y(cyc)
Gene Description	purinergic receptor P2Y, G-protein coupled, 12
GeneID	64805
Uni ProtID	Q9H244
mRNA Refseq	NM_022788.3
Protein Refseq	NP_073625.1
Chromosome Location	3q24-q25
Pathway	ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
MIM	600515

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