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Human P2RY12 Validated Stable Cell Line-CHO

See other products for P2RY12
Cat.No.
CSC-RG1208
Background
P2Y12 is a Gi-coupled 7TM receptor belonging to the P2Y family of nucleotide receptors. The principle ligand for P2Y12 in vivo is ADP, although it binds with lesser affinity to ATP. P2Y12 is expressed predominantly in platelets, where it mediates ADP-induced stable aggregation and secretion. The antithrombotic drugs clopidogrel and ticlopidine disrupt P2Y12-mediated platelet aggregation, and are indicated in acute coronary syndromes. However, metabolites of each drug that are generated by hepatic cytochrome P450 activity are the actual entities that bind and antagonize P2Y12 directly. Novel P2Y12 antagonists that bind directly to P2Y12 exhibit a faster onset of action, and are undergoing clinical trials.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
P2RY12
Synonyms
P2RY12; purinergic receptor P2Y, G-protein coupled, 12; P2Y purinoceptor 12; HORK3; P2Y12; SP1999; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor; ADPG-R; BDPLT8; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc);
Gene ID
MIM
UniProt ID
Q9H244
Chromosome Location
3q24-q25
Pathway
ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function
ADP receptor activity; G-protein coupled adenosine receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;
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Cat#
Product Name
Titer
Product Size
Species
Price
AD11714Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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Email: info@creative-biogene.com
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CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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