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Human O3FAR1 Stable Cell Line-HEK293

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Cat.No.
CSC-RG0857
Background
GPR120 is a member of the free fatty acid G protein-coupled receptor family that includes GPR40, GPR41 and GPR43, and is activated by unsaturated long chain free fatty acids (Hirasawa et al., 2005). Expression analysis shows that GPR120 is abundantly expressed in intestine. Stimulation of GPR120 by free fatty acids has been shown to promote the secretion of glucagon-like peptide-1 (GLP-1) and activate the ERK cascade (Hirasawa et al., 2005). More recently, Katsuma et al showed that activation of GPR120 by free fatty acids such as linolenic acid inhibits apoptosis of a murine enteroendocrine cell line.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Stability
12 passages (6 weeks of continuous culture)
Ship
Dry ice
Gene Information
Official Symbol
O3FAR1
Synonyms
O3FAR1; omega-3 fatty acid receptor 1; G protein coupled receptor 120 , G protein coupled receptor 129 , GPR120, GPR129; PGR4; G protein-coupled receptor 120; G protein-coupled receptor 129; G-protein coupled receptor 120; G-protein coupled receptor 129; G protein-coupled receptor PGR4; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; G-protein-coupled receptor GT01; GT01; BMIQ10; GPR120; GPR129; MGC119984; DKFZp686F0824;
Gene ID
MIM
UniProt ID
Q5NUL3
Chromosome Location
10q23.33
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Free fatty acid receptors, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem;
Function
fatty acid binding; receptor activity; signal transducer activity; taste receptor activity;

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